Open Access

Bruno Kluwe, Marcus Löffler, Yaser Hadadian, Christian Fiedler, Silvio Dutz, Frank Wiekhorst

• Magnetic Particle Imaging (MPI) is an emerging tomographic modality recognized for its capability of directly detecting magnetic nanoparticles (MNPs), enabling real-time 3D imaging with high sensitivity. Since its introduction in 2005, various preclinical MPI scanners have been developed, but cross-platform comparisons lack due to missing standardized phantoms and operation protocols. Recently, efforts towards development of human-sized MPI have intensified. To facilitate the transition beyond the preclinical research phase, harmonization of MPI technology is essential. Within the "harmoMPI" project, we seek to develop platform-independent, modular phantoms that enable reliable assessment of key performance parameters for a consistent performance evaluation across different MPI systems. With the support from the MPI research community, the "harmoMPI" initiative aims to harmonize MPI technology, advance collaboration research, and pave the path toward clinically relevant applications.